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Manufacturing Services Switzerland

Services

Together with our longstanding network of carefully selected SWISS associates and unique subcontractors (CRO/CDMO) that are fully committed to comply with our various agreements and policies we are offering a reliable, comprehensive and transparent service for:

Custom / Contract Manufacturing (cGMP and non-GMP)
Custom synthesis on FTE & FFS service model (CRO)
Literature and Patent Research
Process Research
Process Development
Bench-Scale Lab, Kilo Lab and Pilot Plant Development
Process Optimization
Commercial manufacturing

Core Technologies

Acylation
Amination
Azidation
Bromination
Carboxylation
Chlorination
Chlorosulfonation
Dehalogenation
Diazotisation
Diels-Alder
Etherification
Friedel-Crafts
Grignard
Heterocyclic Synthesis
Hydrogenation
Mannich
Nitration
Oxidation
Phosgenation
Reduction
Sulfonation
Thiocarbonylation
Tosylation

Fast Track projects for GMP or non-GMP

Multipurpose Plants: 
40 m3 total reactor-capacity. 11 stainless steel units (450 - 4500 L), 6 glass lined units (2000 – 4900 L), 1 glass lined pressure reactor up to 24 bars suitable also for hydrogenations.

Several scrubbers to retain corrosive gases.

2 Distillation columns (up to 5 m3/h), 1 wiped film distillation (up to 700 L/h), 2 extraction columns.

4 centrifuges (200 - 400 kg), 1 suction filter dryer (1 m2), 1 vacuum paddle dryer (6000 L), 1 vacuum tray dryer (20 m2, corrosion resistant). 2 clean rooms (ISO 8) for API and API intermediates isolation and packaging.

Pilot: 
120 L glass reactor with distillation column, 120 L and 450 L stainless steel, 270 L glass lined pressure reactor up to 6 bars also suitable for hydrogenations.

Scrubber to retain corrosive gases.

Suction filter 60 L, pressure filter 100 L. Corrosion resistant vacuum tray dryer.

Clean room (ISO 8) for API and API intermediates isolation and packaging.


Phosgenation: 
Modern phosgene generator, 4500 L glass lined reactor in special isolated and dedicated containment featuring state of the art safety standards.

10-40 kg phosgene/h

Synthesis of super fine chemicals

Azido Building Blocks for Click chemistry
Bioactive molecules
Dipeptides
Fluorescent substances
Organic pollutants & pesticides
Pharma actives
Pseudoprolines
in milligrams to kilograms under non-GMP conditions

Nanomedicine
developing leading-edge technology into new diagnostic and therapic modalities,
e.g. to treat atherosclerosis, cancer
Malaria nanopill
In vitro cell transfection

Biologics Development and Manufacturing


Fed-batch, N-1 perfusion and full perfusion processes up to Pilot Scale (200L Non-GMP)

Services include
Cell Line Development
Process Development / Optimization
Method Development
Pilot scale manufacturing
Next Generation Technologies
Technology Transfer
Process Characterization
Support for BLA/MAA submissions
High Titers, up to 14g/L
Any protein format (monoclonal antibodies, bispecifics, fusion proteins, viral proteins)

Precision Fermentation

Equipped for microbial strain development
fermentation optimization
pilot-scale process advancement
Services from the lab bridges discovery to pre-commercial scale-up and validation