Manufacturing Services China

Services

Together with our longstanding network of carefully selected CHINESE associates, joint ventures and unique subcontractors (CRO/CDMO) that are fully committed to comply with our various agreements and policies we are offering a reliable, comprehensive and transparent service for:

Custom / Contract Manufacturing / Tolling (CRAMS/CMO)
Custom synthesis on FTE & FFS service model (CRO)
Literature and Patent Research
Process Research
Process Development
Bench-Scale Lab, Kilo Lab and Pilot Plant Development
Process Optimization
Commercial manufacturing

Core Technologies

Scales ranging from milligrams to multi-ton quantities depending on molecule and requirements.

Acylation
Alkylation
Asymmetric synthesis
Azide reaction
Carbohydrate chemistry
Carbonylation
Catalytic air oxidation
Cross coupling reaction
Enzymatic catalytic reaction
Esterification
Fluorination (HF, KF, DAST, NFSI, …)
Friedel-Crafts reactions
Grignard reaction
Halogenation
Hetercyclic chemistry
High pressure reactions
Hydrogenation
Lithium chemistry
Low temperature reactions
Nitration
Nucleoside chemistry
Oxidation
Reductions

TIDES: Nucleotides, Oligonucleotides and Peptides

Oligonucleotides:
Small to commercial-scale cGMP and non-GMP manufacturing by liquid phase synthesis (LPS)
Small-scale by solid phase synthesis (SPS)
Custom manufacturing with modifications to backbone linkages, sugars, bases
Multi-scale cGMP and non-GMP manufacturing of side-chain and linker drug modifiers

Multiscale cGMP and non-GMP manufacturing of high-purity nucleotides including nucleoside phosphoramidites

Peptides:
Small to commercial-scale cGMP and non-GMP manufacturing by liquid phase synthesis (LPS)
Small-scale manufacturing by solid phase synthesis (SPS)
Custom synthesis of natural and unnatural amino acids
Multi-scale cGMP and non-GMP manufacturing of side-chain and linker drug modifiers

Phytochemicals / Extracts / Natural APIs

Extensive expertise in:
R&D and manufacturing of high quality
phytochemicals, extracts
and natural active pharmaceutical ingredients including

Experimental study, isolating various active ingredients
from herbs for preclinical early activity screening.

CMC study, pilot scale production for clinical trials I and II.

Commercial production, DMF support, API in line with e.g. FDA requirements

Complex synthesis including ADC linkers, payloads and Conjugates

Development
scale-up and
commercial manufacturing of linkers-payloads