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Manufacturing Services in Europe

Services

Together with our longstanding network of carefully selected EUROPEAN associates and unique subcontractors (CRO/CDMO) that are fully committed to comply with our various agreements and policies we are offering a reliable, comprehensive and transparent service for:

Custom / Contract Manufacturing / Tolling (cGMP and non-GMP)
Custom synthesis on FTE & FFS service model (CRO)
Literature and Patent Research
Process Research
Process Development
Bench-Scale Lab, Kilo Lab and Pilot Plant Development
Process Optimization
Commercial manufacturing

Commercial production (up to 100 MT) involving:

Acid chloride preparations
Carbene additions
Cyanations
Cyclopentadiene chemistry
Cyclopropanation
Diazoacetate reactions
Diazotizations
Friedel-Crafts reactions and isomerizations
Halogenations
High temperature reactions
Hydrogenations
Optical resolutions
Oxidations
Reductions

Cryogenic reactions at up to 1,000 litre scale routinely handle
Grignard reagents
Hexyl lithium
Metal hydrides
Organozinc reagents

Special experience in metal-mediated coupling reactions
Heck
Sonagashira
Suzuki

Supporting cGMP up to pilot plant scale

 

Fast Track projects for non-GMP up to 250 MT involving

Acid halides synthesis
Amidation
Bromination (for e.g. 3-4 step synthesis)
Coupling (Suzuki, Kumada…)
Cyclization
Dehydration
Dehydrohalogenation
Esterification (including tert-butyl esterification)
Friedel and Crafts
Grignard reagents synthesis and use
Ketalisation
Metalation (n-Butyllithium) or organometallic reactions
Reduction (Wolff Kishner or Hydrides)

Tolling Service on Large Scale (1000 MT+) involving

Acetylation
Chlorination
Hydrogenation
Ketonization

New R&D projects (non-GMP) up to pilot scale involving

Catalytic hydrogenation
High temperatures and pressure reactions (up to 500°C and 500 bar)
Great expertise with thiols, thiolanes, 1,3-dithianes, thioamides, thioethers, disubstituted cyclohexanes, carboxylic acid, crown ethers, styrenes, substituted oxiranes, modified polyethylene glycols, nitrostyrenes, arylacetylenes.
Capacity: several hundreds of kilos.